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PIs FINE-TUNE CELLULAR SIGNALING

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PIKKs--the solenoid nest where partners and kinases meet. The structural basis for mTOR function. Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. Allosteric activation of PI3Kalpha by oncogenic mutations. Connecting with an old partner in a new way.

Sience Signaling 5, ra Proc Nat Acad Sciences.

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USA 38 Bycroft, M. Structure 20, Hon, W-C, Berndt, A. Science Signaling , 4 , re2. Structure 19, Zhang, X. Cell Hadders, M, Williams R Kinases charging to the membrane. Autophagy 6: Science Nat Chem Biol 6: Biochem Soc Trans. Samson, R. Basis of PhosphatidylinositolPhosphate Specificity. Williams, R. Nat Rev Mol Cell Biol EMBO J Biochem Soc Symp. Li S, Sandercock A.

Cell Biol. Knight, Z. Teo, H. Cell 7: Gonzalez, B. Krugmann S.

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